The shortcut Alt+Shift+F2 is to save the workbook. This is the same as the shortcut "Ctrl+S".
Step 1: If you are working on a worksheet, click anywhere in the worksheet;
Step 2: Press and hold the key "Alt" and "Shift" from the keyboard, then press the key "F2";
Step 3: Browse to the place where you want to save the file, type the file name and click "OK" to save the file.
Alternatively, you can always use the commands in the ribbon to save your work.
Step 1: Click the "File" tab from the ribbon;
Step 2: Click "Save" if this is the new file, or click "Save as" if you want to change the file name or location;
Step 3: Browse to the place where you want to save the file and save the file.