The shortcut Ctrl+Alt+Shift+F9 is to check dependent formulas, then calculate all cells in all open workbooks (see how to set Calculation Option to Manual).
Step 1: Click the cell, e.g., Cell B3;
Step 2: Change the value in the cell from 4 to 6;
Step 3: Press and hold the Ctrl, Alt and Shift keys, click the F9 key to have the calculated results.